thr77 Secrets

thr77 Secrets

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If an Invitrogen™ antibody does not conduct as described on our Web site or datasheet,we will exchange the product at no cost to you, or supply you with a credit for a foreseeable future acquire.*

The antibody is from purified rabbit serum by affinity purification by using sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

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Overexpression of the gene has become observed in several tumors, which ends up in chromosome instability, and therefore may perhaps add to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in mobile-cycle regulated histone gene expression and performs a vital function in endorsing mobile-cycle progression during the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, are described. Two supplemental splice variants ended up noted but in-depth nucleotide sequence information isn't nevertheless obtainable.

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Blocking peptides are peptides that bind exclusively to the goal antibody and block antibody binding. These peptide commonly contains the epitope acknowledged because of the antibody.

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This guideline outlines further more doable optimization of cellular and immunoassay parameters to make sure the very best effects are...

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This information outlines even more doable optimization of mobile and immunoassay parameters to guarantee the very best effects are...

Antibodies sure to the blocking peptide no more bind to your epitope around the target protein. By comparing the staining from your blocked antibody versus the antibody alone, you can see which staining is precise.

Focus on Facts Cyclin E belongs on the very conserved cyclin loved ones, whose members are characterized by a extraordinary periodicity in protein abundance from the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins show distinct expression and degradation styles which lead for the temporal coordination of each mitotic party. Cyclin E kinds a fancy with and features as being a regulatory subunit of CDK2, whose action is needed for cell cycle G1/S transition. This protein accumulates for the G1-S phase boundary and is also degraded as cells progress via S period.

The measurement of protein phosphorylation is a great click here tool for measuring the modulation of receptor activation by both antibodies...

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Clicking the pictures or inbound links will redirect you to definitely a website hosted by BenchSci that provides third-occasion scientific written content. Neither the content material nor the BenchSci engineering and processes for selection are evaluated by us; we've been delivering them as-is and devoid of guarantee of any variety, together with to be used or software in the Thermo Fisher Scientific goods introduced.